International generic name
Drug form and composition
Solution for injection. One ampoule of 2 ml contains 200 mg of Ascorbic acid
(100 mg/ml). One ampoule of 5 ml contains 500 mg of Ascorbic acid (100 mg/ml).
Vitamin C deficiency, when the oral treatment is not enough effective; a treatment
of idiopathic methemoglobinemia in infants and small children.
Dosage and administration
The drug is used parenterally - intramuscularly and intravenously. In the adults,
intramuscularly the drug is given in a dose of 100 to 500 mg daily for a period
of at least 2 weeks. In children, intramuscularly the dose is 100 to 300 mg daily
for at least 2 weeks. The maximum recommended intravenous dose in children bellow
17 years is 100 mg/kg daily (maximum up to 6 g daily). The recommended dose for
the treatment of idiopatic methemoglobinemia in infants and small children is 500
mg to 1 g daily.
Hypersensitivity to the drug; hyperoxaluria; nephrolithiasis. The drug is not
used in high doses, especially intravenously, in patients with increased blood coagulation,
thrombophlebitis, tendency to thromboses.
Special warnings and precautions
Fast intravenous injection of the drug should be avoided. In cases of glucose-6-phosphate
dehydrogenase deficiency, doses over 2 g daily can induce hemolysis.
Vitamin C is a component of combined multivitamin products. It must not be combined
in one syringe or infusion solution with antibiotics, neuroleptics, tranquilizers,
etc. In high doses it can not be combined with insulin products and oral antidiabetic
The preparation shows good tolerance. In rare cases it can induce allergic reactions.
Vitamin C (ascorbic acid) is a typical “redox” compound. It can transfer reciprocally
hydrogen ions, respectively electrons, and due to this it influences the intracellular
oxidation-reduction processes. Vitamin C improves the internal tissue breathing.
It was called an universal activator of the cellular metabolism. It increases the
synthesis of specific antimicrobial antitoxins and improves the function of the
reticuloendothelial tissue: decreases the passability of the border membranes -
increases the capillary stability and limits the exudative, inflammatory, and allergic
reactions; acts desensitizating on the organism. It exerts a hemostatic action.
The ascorbic acid participates in synthesis and metabolism of the corticosteroids
and epinephrine. It improves the appetite and stimulates growth in the young individuals.
It is of importance for the formation of colloids that support the structure of
the bones, teeth, muscles, and blood vessels. Vitamin C participates in the carbohydrate
metabolism, improving the glucose and pyruvate utilization in the cycle of Krebs.
It regulates the metabolism of the aromatic amine acids (thyrozin, phenylalanine).
The vitamin is consumed actively in febrile states.
10 ampoules of 2 ml (200 mg). 10 ampoules of 5 ml (500 mg).