International generic name
Drug form and composition
Solution for injection. One ampoule of 2 ml contains: 10 mg (5 mg/ml) Thiamine
hydrochloride (vitamin B1), Riboflavine Sodium Phosphate equ. to 2 mg (1mg/ml) Riboflavin
(vitamin B2), 10 mg (5 mg/ml) Pyridoxine hydrochloride (vitamin B6), 100 mg (50
mg/ml) Nicotinamide (vitamin PP). Film-coated tablets. One tablet contains: 5 mg
Thiamine nitrate (vitamin B1), 1 mg Riboflavine (vitamin B2), 4 mg Pyridoxine hydrochloride
(vitamin B6), 50 mg Nicotinamide (vitamin PP).
Vitamin B complex is indicated in following diseases, manifesting with a vitamine
B deficiency: neuritis; alcohol, toxic, and post infectious polyneuritis; diabetic
polineuropathy; neuralgia; sciatica; central spastic conditions; myasthenia; paresthesia;
atherosclerosis; Wernicke’s encephalopathy; vegetative neurosis; dermatitis; neurodermatitis;
psoriasis; lupus erythematodes; furunculosis; stomatitis; cheilitis; glositis; colitis;
hepatitis; chronic alcohol abuse; asthenia; anemia; intoxications.
Dosage and administration
The solution for injection is applied parenterally - intramuscularly or (rarely)
intravenously in dose 1-2 ml daily or each second day, within 5-10 days. The film-coated
tablets are used orally in following doses: adults - 2-6 tablets daily; children
1-2 tablets daily.
Vitamin B complex should not be used in hypersensitivity to any of the vitamins,
containing in the preparation, as well as in patients with 2-nd or 3-rd degree arterial
Special warnings and precautions
Because of in vitro incompatibility the preparation should not be used simultaneously
(in the same syringe) with following preparations: Benzilpenicillin and oxacyllin
(the antibiotic precipitates and is inactivated), macrolides (insoluble sedimentation
is formed); Chloramphenicol (precipitation); Vitamin B12 (cobalt ions destruct vitamin
B2); Vitamin C (inactivates vitamin B6). The preparation could be used in pregnant
and nursing women.
The preparation may reduce the antihypertensive effect of some adrenoreceptor
blockers and adrenolytics, as well as to decrease the hypnotic effect of barbiturates
and glutethimide, due to vitamin B1 persistence. Chlorpromazine increases the urine
excretion of the vitamin B2. Probenecid inhibits tubular excretion and reabsorption
of the vitamin B2, reducing its excretion in urine. Vitamin B6 reduces the antiparkinsonic
effect of L-Dopa. In concomitant treatment with oral contraceptive agents, isoniazid,
penicillamine, cicloserin, and thiosemicarbazones the blood concentration of vitamin
B6 is reduced.
Although the preparation is very well tolerated, in rare cases in predisposed
patients itching, urticaria, and Quincke’s edema may appear.
Vitamins belonging to group B possess a biology activity in low concentrations
and exert a regulating effect on the cell function. They participate in number of
enzyme systems and in such a manner in the regulation of carbohydrate, protein and
lipid metabolism. After the conforming to pyrophosphate Vitamin B1 participates
in the carbohydrate, and protein metabolism, as well as in synthesis of nucleic
acids as a co-enzyme. It influences the neural impulse conduction in the synapse.
Vitamin B2 improves the carbohydrate and lipid metabolism, and is related to aminoacid
metabolism. It participates in iron and porphyrin exchange, in hemoglobin synthesis
and in the tissue respiration. Vitamin B6 is a part of following enzymes: decarboxylase
and transaminase. It participates in histamine, free fatty acid, and aminoacid metabolism.
The vitamin plays a role in the normal functioning of the central and peripheral
nervous system, skin, and gastrointestinal tract. Nicotinic acid and its amide are
included in co-dehydrases, participating in the hydrogen transport and in oxygenation-restoration
processes, necessary for the tissue respiration.
10 or 100 ampoules of 2 ml. 20 film-coated tablets.
Solution for injection and film-coated tablets - 2 years