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International generic name
Riboflavin
Drug form and composition
Solution for injection. One ampoule of 2 ml contains Riboflavine Sodium Phosphate
equ. to 10 mg Riboflavin (5 mg/ml).
Indications
Lack of vitamin B2, when oral treatment is not enough effective in following
conditions: burning; chronic febrile states; gastrectomy; liver and biliary ducts
diseases (alcoholism with cirrhosis, obstructive jaundice), hyperthyroidism; prolonged
infections; intestinal diseases (tropical sprue, enteritis, persistent diarrhea);
malignant tumors; prolonged stress.
Dosage and administration
The drug is used by parenteral route (intramuscularly or intravenously) in a
daily dose - 5 to 20 mg. The treatment course depends on the severity of the disease.
After getting control of the clinical picture the treatment can be continued by
oral drug administration.
Contraindications
Hypersensitivity to the preparation.
Special warnings and precautions
Because of different types of incompatibility, administration in one syringe
is unallowable with: benzylpenicillin and oxacillin (antibiotic inactivation and
precipitation); macrolides (formation of unsoluble sediment); chloramphenicol (precipitation);
vitamin B1 (vitamin B1 oxidation); vitamin B12 (vitamin B2 destruction by the cobalt
ions); vitamin C (vitamin B2 inactivation).
Drug interactions
No clinically significant adverse drug reactions in cases of concurrent administration
of vitamin B2 with other drugs have been reported.
Adverse reactions
In some cases, pain in the place of drug application can be observed. After administration
of high doses hypergranulate (changes in oral mucosa) can occur.
Pharmacological mechanisms
Vitamin B2 is widespread in the nature. It has also been produced synthetically.
The vitamin enters in the body predominantly with the food (beer, liver, eggs, meat,
fish, milk, wheat germs, etc.) It plays role in the oxidation-reduction reactions
in the body. After entering in the organism vitamin B2 interacts with adenosine
triphosphate acid and forms nucleotide compounds, which represent coenzymes of flavin
proteins, participating in the transmission of the hydrogen ions and in the regulation
of the oxidation-reduction reactions. It facilitates carbohydrate metabolism, improves
disturbed lipid metabolism, and it is related to the metabolism of the amine acids.
Vitamin B2 influences the iron and porphyrin metabolism, hemoglobin synthesis, and
cellular breathing.
Supplied
10 or 100 ampoules of 2 ml (10 mg).
Expiry
2 years
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