International generic name

Tilidine

Drug form and composition

Solution, oral drops. 1 ml (10%) solution contains 100 mg Tilidine hydrochloride.

Indications

Valoron is used in severe pains related to malignant diseases; spastic states, associated with severe pain originating from the gastrointestinal tract, urinary and biliary tracts; postoperative pain, neuralgia, and particularly neuralgia of the trigeminal nerve.

Dosage and administration

In the adults, the drug is used orally in dose of 5 - 20 drops 3 - 4 times daily. In children from 2 - 14 years, the dose is 1 drop per 1 year of age, 3 - 4 times daily. In children between 11 and 14 years, the dose should not exceed 10 drops.

Contraindications

Hypersensitivity to the drug, pregnancy and lactation, renal failure.

Special warnings and precautions

Valoron should be used in lower doses in patients with kidney diseases, because the elimination is disturbed. In acute myocardial infarction patients, it must be used cautiously. Alcohol should be avoided during the treatment with this drug. It must not be used during car driving and working with machines.

Drug interactions

Valoron augments the central depressive action of alcohol, analeptics, analgesic agents, barbiturates, and tranquilizers.

Adverse reactions

Headache; dizziness; orthostatic collapse; nausea; vomiting.

Pharmacological mechanisms

Valoron is a synthetic narcotic analgesic agent of the group of phenylaminocyclohexanes. It exerts powerful analgesic action against different types of pain. Generally, the efficiency of the drug in extero- and proprioceptive pain is higher compared to the nonnarcotic analgesics. Its analgesic activity, as well as a number of other effects, are related to the activation of specific opioid receptors in the central nervous system, which regulate anti-nociception. It also exerts a spasmolytic action.

Supplied

Vials of 10 ml (100 mg/ml) solution and drop device.

Expiry

3 years