International generic name (More at www.tabex.net)
Drug form and composition
Film-coated tablets. One film-coated tablet contains 1.5 mg Cytisine.
Smoking cessation in smokers.
Dosage and administration
The product is used orally according to a scheme: first 3 days 1 tablet 6 times
daily (at an interval of 2 hours) associated with reduction in number of the cigarettes
used. In cases of good effect the treatment continues according to the following
scheme: day 4 to 12 - 1 tablet at an interval of 2.5 hours (5 tablets daily); day
13 to 16 - 1 tablet at an interval of 3 hours (4 tablets daily); days 17 to 20 -
1 tablet at an interval of 5 hours (3 tablets daily); days 21 to 25 - 1 to 2 tablets
daily. Smoking should be stopped approximately at day 5 after the beginning of the
Tabex is contraindicated in hypertensive patients, severe atherosclerosis, pregnancy,
Special warnings and precautions
Tabex should be used only in patients, which seriously intend to stop smoking.
The patient must be warned that Tabex use together with persisting smoking can lead
to increased adverse nicotine effects. In patients suffering from ischemic heart
disease, heart failure, cerebrovascular diseases, arterial diseases with obliteration,
hyperthyroidism, diabetes, renal and hepatic failure, Tabex should be used after
careful assessment by the physician.
There are no data for any clinically significant drug interactions of Tabex with
The most frequent adverse reactions after the beginning of the treatment using
Tabex are: changes in taste and appetite, dry mouth, headache, increased irritability,
nausea, constipation, tachycardia, slightly elevated blood pressure. These reactions
disappear during the treatment.
Tabex has been created using the plant cytisine, which is an alkaloid with N-cholinomimetic
action. Cytisine stimulates the autonomic nerve ganglia and by a reflex pathway
stimulates breathing, induces release of epinephrine form the suprarenal glands
and elevates blood pressure. The aim when using Tabex is to replace nicotine, entering
in the body during smocking, by cytisine taken orally. The mechanism of the cytisine
action is similar to nicotine. Because of this fact gradual cessation of smocking
can be achieved and abstinence is avoided.
100 film-coated tablets of 1.5 mg.