International generic name
Drug form and composition
Tablets. One tablet contains 100 mg Isoniazid. Solution for injection. One ampoule
of 2 ml contains 50 mg Isoniazid (25 mg/ml).
Rimicid is a tuberculostatic agent of first order and it is used in all forms
of tuberculosis in combination with other antimicrobial agents. In patients susceptible
to this disease (diabetics, patients on systemic corticosteroid treatment), Rimicid
can be used for chemoprophylaxis of tuberculosis.
Dosage and administration
In adults: Preventive administration - the drug is given as a single agent intramuscularly
or orally route in a dose of 300 mg once daily. For a treatment in combination with
other tuberculostatic drugs (orally or intramuscularly) in a dose of 5 - 10 mg/kg
body weight daily, but not exceeding 600 mg daily. In children: Preventive administration
- Rimicid is given as a single agent intramuscularly or orally in a dose of 10 mg/kg
body weight, up to 300 mg daily. For a treatment in combination with other tuberculostatic
drugs using orally or intramuscularly in a dose of 10 - 20 mg/kg body weight, up
to 500 mg daily.
Rimicid is not used in cases of hypersensitivity to this drug, alcoholism, hepatic
dysfunction, renal failure, epilepsy and other seizure states.
Special warnings and precautions
Because the drug disturbs the liver function, during the treatment it is necessary
to perform regular checks of the hepatic function using serum transaminase levels.
The people showing hypersensitivity to ethionamide, pyrazinamide, hiacin, and other
drugs, shows higher risk of development of hypersensitivity manifestations because
of cross allergy. In patients regularly using great quantities of alcohol, patients
suffering form epilepsy, or with severe renal diseases, the dosing regimen should
be modified according to the creatinine clearance. During pregnancy and lactation
Rimicid can be used only after careful assessment of the indications and risks for
the fetus. During the treatment with Rimicid, increased attention during car driving
and working with machines is necessary because of the possibility of development
of dizziness and psychic disturbances in some patients.
The drugs containing aluminum hydroxide decrease intestinal absorption of Rimicid.
Combination with rifampicin, streptomycin, or ethambutol leads to avoiding selection
of resistant tuberculosis strains. Rimicid elevates the plasma levels and the toxicity
of the hydantoin antiepileptic drugs. In cases of concurrent administration with
disulfiram psychotic reactions and ataxia have been observed.
Rimicid is a drug with wide therapeutic spectrum. The adverse drug reaction most
commonly are from the central nervous system and the liver: symmetric polyneuritis,
dizziness, headache, ataxia, psychic disturbances, mental problems, susceptibility
to seizures, paresthesia, muscle cramps; risk of development of severe hepatitis.
There is a possibility of gastrointestinal disturbances: nausea, vomiting, pain
in epigastrium, vitamin B6-deficiency; endocrine disorders: hyperglycemia, galactorrhea;
allergic reactions: skin rash, fever, exfoliative dermatitis, lymphadenopathy, vasculitis,
Quincke’s edema. Lupus erythematodes like syndrome, arthralgia, and rheumatic syndrome
are observed relatively rarely.
Rimicid is an antituberculosis drug with a wide spectrum of its bacteriostatic
action and low toxicity. It exerts a fast bactericidal action on the mycobacteria
in the stage of replication and bacteriostatic action against mycobacteria in latent
state. Its activity is weaker than that of rifampicin and pyrazinamide. It acts
both on the intracellular and extracellular mycobacteria. It is transformed into
isonicotine acid which is incorporated in a defective NAD. It binds into a helate
complex the copper ions, which are necessary for the vitality of the mycobacteria.
It disturbs catalase and peroxidase in the mycobacteria, and inhibits synthesis
of DNA and secondarily RNA synthesis. In this process the bacteria are subjected
to great morphologic changes at the level of the lipid membrane.
100 tablets of 100 mg. 10 or 50 ampoules of 2 ml (50 mg).
Solution for injection and tablets-5 years