International generic name
Drug form and composition
Solution for injection. One ampoule of 5 ml contains 1 g Piracetam (200 mg/ml).
Film-coated tablets. One tablet contains 400 mg of Piracetam.
Piracetam, solution for injection is used in cases of severe brain diseases:
cerebro-cranial trauma in acute stage, comatose states, ischemic stroke, acute psychic
disturbances due to intoxications, alcohol delirium. Piracetam tablets are used
in cerebro-vascular disease; degenerative cortical dementia (Alzheimer’s disease);
senile psychoorganic syndrome (“aging brain”); cortical myoclonia; dyslexia of vascular
and other origin; vestibulopathies; protection of the nervous tissue in a brain
hypoxia; postoperative deliriums.
Dosage and administration
Adults: Parenteral administration. The drug is administered intramuscularly,
as a drop intravenous or as a slow intravenous infusion. The recommended 24-hours
dose is 3 - 12 g (depending on the severity of the disease) which should be divided
in 2-4 takes. Oral administration. Starting dose - 800 mg (2 tablets), 3 times daily.
After the desired effect has been achieved the dose can be reduced to 400 mg (1
tablet), 3 times daily. Children: 400 mg 2 or 3 times daily. Administration of the
drug after 04:00 h P.M. should be avoided because of its exciting action and the
possibility of disturbing the night sleep of the patient. The duration of the treatment
course is 2 - 3 months, but in severe cases the drug can be used for a period of
6 - 12 months.
First trimester of pregnancy; severe parenchymal liver or kidney diseases; agitated
depression, particularly in the elderly.
Special warnings and precautions
In patients suffering from liver diseases, a monitoring of the liver enzymes
and function is necessary. In patients with renal failure, the 24-hours dose should
be adjusted according to the creatinine clearance. The levels of the residual nitrogen
and creatinine should be checked regularly. Because of the distribution into breast
milk the breast-feeding should be discontinued for the period of the treatment.
Piracetam increases the effects of the drugs stimulating the CNS, thyroid hormones
and oral anticoagulants. The concurrent administration of neuroleptics increases
the risk of hyperkinesia.
Rarely in susceptible patients can be observed the following symptoms: increased
aggressiveness, headache, sleep disturbance, gastrointestinal problems, blood pressure
Piracetam is a nootropic agent. It improves the metabolic processes in the brain
cells, possesses an antihypoxic action, accelerates the reparative processes in
functionally damaged cells after traumas, intoxications, and stoke. Piracetam acts
selectively on the telencephalon, improving its associative functions. The drug
has an antiplatelet and a microcirculation ameliorating action. The therapeutic
effect of Piracetam is manifested after prolonged treatment (several weeks to several
10 or 50 ampoules of 5 ml (1 g). 40 film-coated tablets of 400 mg.
Solution for injection- 5 years. Tablets -3 years