International generic name
Drug form and composition
Solution, eye drops. One vial of 10 ml (1%) contains 100 mg of Pilocarpin hydrochloride
(10 mg/ml). One vial of 10 ml (2%) contains 200 mg of Pilocarpin hydrochloride (20
Glaucoma (open angle, closed angle glaucoma, secondary glaucoma); for induction
of myosis after surgery and after ophthalmoscopy; before iridectomy.
Dosage and administration
In chronic glaucoma, 1 - 2 drops of Pilocarpin solution (1% or 2%) are applied
in the conjunctival sack 2 - 4 times daily, depending on the intraocular pressure.
In acute open angle glaucoma, the preparation is used on the conjunctiva in a dose
of 1 drop of 1% or 2% solution every 5 to 10 minutes (from 3 to 6 doses) and after
that 1 drop every 1 - 3 hours up to the intraocular pressure reduction. For myosis
induction the preparation is used on the conjunctiva in a dose of 1 drop 1% or 2%
Hypersensitivity to the drug; iridocyclitis.
Special warnings and precautions
Pilocarpin is used with increased caution in cases of severe heart failure, bronchial
asthma, hyperthyroidism, peptic ulcer, disturbed urinary bladder emptying, stenotic
changes in the gastrointestinal tract and urinary passages. In pregnancy and lactation,
the preparation is used after a strict assessment of the risk/benefit ratio. During
the treatment with Pilocarpin there is a possibility of visual disturbances, because
of which driving and working with machines should be avoided.
In chronic interventions should be kept in mind that Pilocarpin potentiates the
action of the curare type agents. Atropin and other M-cholinolytics are Pilocarpin
antagonists. Combination of the preparation with myotics and adrenomimetics is possible.
Myosis; visual disturbances; transitory accommodation spasms, generally disappearing
up to the second hour after drug administration; lacrimal secretion increase, conjunctival
vasodilation, contact allergy in susceptible patients.
Pilocarpin is a direct parasymatholytic agent and directly acts on the M-cholinoreceptors.
When used in the conjunctival sack, myosis and accommodation spasm follow due to
stimulation of the cholinoreceptors in m. sphincter pupillae and m. ciliaris. In
cases of increased intraocular pressure, lowering of this pressure follows. In the
ophthalmology this drug is used widely for the treatment of glaucoma (facilitates
of intraocular fluid drainage through the canal of Schlemm) and for improvement
of eye trophics. The drug is also used for termination of mydriasis after atropine
use. The myosis develops after 15 minutes and lasts for several hours.
Vials, containing 10 ml (1%) solution. Vials, containing 10 ml (2%) solution.