International generic name

Sodium chloride

Drug form and composition

Solution for injection. One ampoule of 5 ml (0.9%) contains 45 mg Sodium chloride (9 mg/ml). One ampoule of 10 ml (0.9%) contains 90 mg Sodium chloride (9 mg/ml).

Indications

The isotonic solution is applied as a solvent for preparation or dilution of parenterally applied medicines.

Dosage and administration

The isotonic solution of sodium chloride is applied as an intravenous injection in quantities, sufficient for the particular case.

Contraindications

The solution should not be applied in hypernatremia and hyperchloremia.

Special warnings and precautions

The solution should be used with care in heart failure, generalized edemas, pulmonary edema; arterial hypertension; eclampsia; severe renal failure.

Drug interactions

Sodium chloride increases solubility and absorption of the mercury dichloride. Sodium and lithium ions are reabsorbed concurently in the renal tubule, which may enhance the toxicity of the sodium* ions.

Adverse reactions

In correct application no adverse effect was seen.

Pharmacological mechanisms

The sodium ion plays an important role in maintaining of the osmotic balance of the tissue liquids. Its concentration in the blood is almost 0.5%, which maintains the osmotic pressure of the blood constant. The sodium ion is the most important extracellular ion, related to the transmembrane action potential realization.

Supplied

50 ampoules of 5 ml (45 mg). 50 ampoules of 10 ml (90 mg).

Expiry

5 years.