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International generic name
Potassium chloride
Drug form and composition
Solution for injection. One ampoule of 10 ml contains 1.5 g Potassium chloride
(0.15 g /ml).
Indications
Cardiac rhythm disorders due to intoxication with digitalis glycosides, and hypokalemia
of different causes - thiazide diuretics overdosage, treatment with corticosteroids
and purgative agents.
Dosage and administration
The solution is applies as an intravenous infusion; 1.5-3 g Kalium chloratum
(1-2 ampoules) is diluted in 500 ml 5% glucose solution. In patients with severe
digitalis glycoside intoxication 3 g Kalium chloratum, diluted in 500 ml 5% Glucose
solution, is applied intravenously (intravenous drop infusion within 1 hour); the
dose should not exceed 1.5 l /24 hours solution. Kalium chloratum should not be
used in dose higher than 1.5 g per hour.
Contraindications
Hyperkalemia of different causes; Addison’s disease; no controlled diabetes;
renal failure; ulcer disease; acute dehydration; oliguria; anuria; hyperchloremia.
Special warnings and precautions
Intravenous application of the preparation should be made very slowly, under
close control of the blood pressure. The preparation should be used with great attention
in pregnant and nursing women.
Drug interactions
Concomitant administration of potassium iodide and iodine containing X-ray-contrast
media reduces the preparation effectiveness. Combination with ACE-inhibitors, anticholinergic
drugs, β-adrenergic blockers, heparin, and potassium-spearing diuretics is not advisable.
Adverse reactions
Kalium chloratum may cause following adverse reactions: heart rhythm disorders;
paresthesias; nausea; vomiting; diarrhea; epigastral heaviness; gastrointestinal
tract ulcerations.
Pharmacological mechanisms
Potassium ions play an important role in the electrolyte balance of the cells
and have an important significance in nervous impulse conduction, in muscular contraction,
and in heart automaticity maintaining. The sodium/potassium ions ratio in the cell
is of main significance in the proper functioning of the myocardium, vegetative
tone maintaining, and protein and glycogen exchange. Potassium ions participate
in the maintaining and excitation of the sympathetic nervous system. They possess
a moderate diuretic effect also.
Supplied
50 ampoules of 10ml (1.5mg).
Expiry
5 years
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