International generic name
Drug form and composition
Solution for injection. One ampoule of 10 ml contains 1 g (10%); 2 g (25%) or
4 g (40%) Glucose anhydrious.
The solution is applied in pulmonary edema, brain hemorrhage, uremia, acute infections.
Dosage and administration
The preparation is applied intravenously in quantities relevant to the particular
case. In adults the maximal dose is 28 ml/kg/24 hours.
The solution should not be applied in diabetes, hypokalemia, hyperhydration,
hypotonic dehydration, acidosis, and renal failure.
Special warnings and precautions
Before administration of the hypertonic solutions glucose serum level should
Concomitant administration with adrenalin and narcotics prologs their action.
Intravenous application of hypertonic glucose solutions may cause local irritation
of the vascular wall. In long-term administration hypophosphatemia may appear.
Glucose is a carbohydrate alimentary substance, which after oxidation is transformed
to the basic energy source. In this manner is provided energy for the functioning
of the nervous and cardiovascular system, skeletal muscles and all intensive functioning
organ cells. Intravenous application of isotonic (4.5-5%) solution acts as a plasma
substitute. Hypertonic solution injecting extracts fluids from the tissues, including
areas with transudate and exudate; improves the metabolism; improves the detoxication
function of the liver; improves contractility of the heart muscle; causes vasodilatation
and increase diuresis. The 40% hypertonic solution facilitates blood coagulation
and reduces nitric substances loss in febrile conditions. It causes denaturation
of the proteins and in this manner acts as a nonspecific protein stimulant of the
50 ampoules of 10 ml.