International generic name
Drug form and composition
Syrup. 5 ml Syrup contains 12 mg Diphenhydramine hydrochloride; 6 mg Codeine
Phosphate Hemihydrate; 100 mg Ammonium chloride.
The preparation is used in inflammatory diseases of the upper respiratory tract;
acute and chronic bronchitis; tracheobronchitis; pertussis. It depresses the irritative
and spastic cough.
Dosage and administration
The syrup is administered in following dosage: children, 6-8 years - 2.5-5 ml
3-4 times daily; children, 9-14 years - 5 ml 3-4 times daily. In adults and children
older than 14 years - 10 ml 3-4 times daily.
Hypersensitivity to any of the preparation ingredients; acute asthmatic attacks;
narrow-angle glaucoma; prostatic gland hypertrophy; ureteral stenosis; pregnancy
and lactation; children younger than 6 years.
Special warnings and precautions
In infants the preparation should be dosed carefully, as it may cause excitation
and convulsions. Usage of the preparation in elderly persons with severe constipation
is not recommended. Dimex should be used carefully in patients with bronchial asthma
because it impedes secretion elimination. During the treatment alcohol consumption
is undesirable. Dimex-Co should not be used in driving and machinery operating persons,
due to possibility to provoke somnolence and coordination disorders.
Hypnotic agents and alcohol potentiate the sedative effect of the preparation.
It should not be combined with MAO-inhibitors. Concomitant treatment with tricycle
antidepressants may cause an additive synergism concerning the anti-cholinergic
effect of the diphenhydramine with resultant urine retention, intestinal atonia,
enhancement of the ophthalmic tone.
Somnolence; nausea; headache; attention disorders; weakness; visual disorders;
blood count changes; insomnia; anxiety; tremor; drug-dependence; constipation.
The three main constituents of the medicine determine its antitussive, secretolytic,
broncholytic and antiseptic action. Diphenhydramine (H1-blocker), influence the
cough reflex, depresses the allergy reactions, reduces the bronchial secretion,
and causes sedative and antiemetic effects. Ammonium chloride liquefies the bronchial
secretion and facilitates its elimination. It exerts some stimulating action on
the respiratory center, which improves the expectoration-stimulating effect. Codeine
phosphate, being an opium alkaloid, improves the antitussive effect of the preparation,
depressing directly and selectively the cough-center in the medulla oblongata. It
possesses some analgesic and sedative effects also.
Vials, containing 125 ml syrup.