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International generic name
Combined product
Drug form and composition
Syrup. 5 ml Syrup contains: 10 mg Diphenhydramine hydrochloride; 100 mg Ammonium
chloride.
Indications
In imitative and spastic cough; cough in inflammatory diseases of the upper respiratory
tract; acute and chronic bronchitis; tracheobronchitis.
Dosage and administration
In children the dosage is as follows: children 1-3 years -2.5 ml 3-4 times daily;
4-8 years - 2.5-5 ml 3-4 times daily; 9-14 years - 5 ml 3-4 times daily. In adults
and children older than 14 years - 10 ml 3-4 times daily. The treatment usually
continues 8-10 days; if necessary the treatment may be prolonged to 25 days.
Contraindications
Hypersensitivity to diphenhydramine; acute asthmatic attacks; narrow-angle glaucoma;
prostatic gland adenoma and uretheral stenosis, causing urine retention; stenotic
peptic ulcer; pregnancy and lactation; children younger than 1 year.
Special warnings and precautions
Dimex should be used carefully in patients with bronchial asthma because it impedes
secretion elimination. In infants antihistamine preparations (mainly in overdosage)
may cause hallucinations, convulsions, and excitation. It should be used with caution
in elderly persons, as it may provoke dizziness, somnolence, and arterial hypertension.
The preparation should be used with caution in driving persons. During the treatment
alcohol consumption is undesirable.
Drug interactions
Dimex potentiates effects of the hypnotic and sedative drugs, anxiolytics, tricycle
antidepressants, MAO-inhibitors, general anesthetics, alcohol and other suppressing
CNS agents.
Adverse reactions
Somnolence; attention disorders; xerostomia; hypotension; constipation; gastrointestinal
manifestations, including nausea and vomiting. Photoallergy reactions and muscle
dystonia were seen.
Pharmacological mechanisms
An antitussive medicine free of opiates. The main ingredient of the preparation
is diphenhydramine (H1-blocker), possessing prominent anti-cholinergic and sedative
effects. Its powerfull anti-cholinergic effect (M-cholinolytic) explains reduction
of the bronchial secretion and the spasmolytic effect of the drug. These effects
are related to its H1 - blocking activity. The antiemetic effect of diphenhydramine
is due to H1 - histamine receptors blocking in the vestibular nuclei, nucleus tractus
solitarii and other brain structures. Ammonium chloride possesses a secretomotor
activity - stimulates the respiratory tract epithelial cilia movement (confirmed
experimentally), directed to the mouth, and facilitates expectoration. It exerts
some stimulating action on the respiratory center, which improves the expectoration-stimulating
effect.
Supplied
Vials, containing 125 ml syrup.
Expiry
3 years.
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