International generic name

Combined product

Drug form and composition

Ointment. 1 g ointment contains 350: UI Vitamin A (Retinol palmitate); 400 UI Vitamin D2 (Ergocalciferol); 10 mg Cod-liver oil; 15 mg Peru balsamum.

Indications

Deflamol is indicated in sunburns, radiation burns, thermal and chemical burns. It is suitable in patients with hyperkeratolytic and chronic eczema and other skin diseases as well as in frost damages. The preparation is effective in psoriasis, in poor healing varicose ulcers and in all diseases, requiring an improvement of the epithelization process.

Dosage and administration

In burns the preparation is spread on the sterile fold-free cloth, which is applied on the affected region. The dressing should be changed each 2-6 days, depending on the healing phase. In sunburns the ointment is spread directly on the affected region 1-2 times daily.

Contraindications

Hypersensitivity to any of active constituents of the preparation.

Special warnings and precautions

In opened wounds is obligatory to observe sterility rules, in order to prevent infection complications. Deflamol should not be applied in eye and other mucous membranes.

Drug interactions

No adverse drug interactions were seen so far.

Adverse reactions

In correct observation of the recommended dose and way of administration no adverse reactions should be expected. Tolerability to the preparation is very good. It does not cause irritation in the place of application. Due to local application it does not causes hypervitaminosis A and D and related complications.

Pharmacological mechanisms

Deflamol possesses a prominent epithelium-stimulating effect and in burns of first, second and third degree contributes to formation of a soft cicatrix with no keloids. In local application the combined preparation Deflamol exerts a favorable effect on the affected skin region, reducing the erythema, swelling, and improving the regenerative capabilities of the epithelium. Vitamin A is of great importance in providing the normal functioning of the epithelium. It participates in protein exchange of the skin and mucous membranes, as well as in synthesis of the visual pigment rhodopsin. It possesses a prominent effect on the regeneration processes in the skin and mucous membranes, mainly by activating the protein synthesis and metabolism in the epithelial cells. The main physiologic function of the vitamin D is related to the calcium-phosphate metabolism in the organism. Vitamin D improves the cell membrane permeability to calcium ions, stimulates the specific protein synthesis, necessary in the gastrointestinal resorption of the calcium, participates in transportation to and deposition of the calcium in the bones. God-liver oil contains vitamin A and vitamin D2, as well as glycerides of the oleic, palmitic and stearic acids; bromine, iodine, and phosphate traces; cholesterol and other ingredients. Its action depends mainly on the vitamin A and D, and no saturated fatty acid content. Peru balsamum possesses softening and weak antiseptic effects.

Supplied

Tube, containing 18 g ointment. Banks, containing 700 g ointment.

Expiry

2 years.