International generic name
Drug form and composition
Tablets. One tablet contains: 10 mg Codeine, 250 mg Terpin hydrate, 250 mg Sodium
The preparation is used in acute and chronic bronchitis; pneumonia; bronchiectases;
chronic obstructive pulmonary disease; infectious and inflammatory diseases of the
upper respiratory tract.
Dosage and administration
Codterpin is administered orally, 1 tablet 3-4 times daily, after nutrition.
Codterpin is contraindicated in hypersensitivity to codein or to some preparation’s
constituents; in respiratory insufficiency; in children younger than 6 years; pregnancy
Special warnings and precautions
The preparation should be used with particular care in respiratory tract diseases
and with strictly observation of the therapeutic dose. Exceptional attention should
be given when using the preparation on elderly patients and patients with debility;
in cases with severe renal or liver failure; prostatic gland hypertrophy or ureteral
sticture. As the medicine may provoke coordination disturbance, it should be used
very carefully on driving and machinery operating persons.
In concomitant administration with alcohol, barbiturates, benzodiazepine, hypnotic
and sedative drugs, MAO-inhibitors and tricycled antidepressants Codterpin leads
to intensification of its central depressive action on the central nervous system.
Concomitant treatment with guanetidin, methyl-dopa and reserpine reduces its antihypertensive
Following adverse reactions may be seen: respiratopry tract - depression of the
respiration; cardiovascular system - hypotension, tachycardia, premature beats;
hematologic - hemolytic anemia, thrombopenia, agranulocytosis; central nervous system
- headache, sedation, coordination disorders, fatigue, insomnia, diplopia, neuritis,
convulsions; gastrointestinal system - xerostomia, appetite loss, nausea, vomiting,
diarrhea, constipation; urinary system - disuria, urine retention. Occasionally
rash and photosensitivity are seen. Long-term administration of the preparation
leads to drug dependence (codeine-dependence) manifesting with abstinence after
Codterpin is a combined preparation possessing antitussive and expectorant action.
Codeine, as a preparation constituent, depresses the cough reflex, inhibiting directly
the cough center in the brainstem. In therapeutic dose it does not depress the respiratory
center. The preparation possesses weak sedative and analgesic effects. Terpin hydrate
facilitates the elimination of the resilient bronchial secretion, as it is excreted
by the lungs and liquefies the secretion. Exerts weak antiseptic effect on the pulmonary
parenchyma. Sodium hydrogen carbonate liquefies the respiratory tract secretion
and facilitates its elimination.
10 or 400 tablets.