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Codterpin, Codeine, Terpin hydrate  
 

International generic name

Combined product

Drug form and composition

Tablets. One tablet contains: 10 mg Codeine, 250 mg Terpin hydrate, 250 mg Sodium hydrogen carbonate.

Indications

The preparation is used in acute and chronic bronchitis; pneumonia; bronchiectases; chronic obstructive pulmonary disease; infectious and inflammatory diseases of the upper respiratory tract.

Dosage and administration

Codterpin is administered orally, 1 tablet 3-4 times daily, after nutrition.

Contraindications

Codterpin is contraindicated in hypersensitivity to codein or to some preparation’s constituents; in respiratory insufficiency; in children younger than 6 years; pregnancy and nursing.

Special warnings and precautions

The preparation should be used with particular care in respiratory tract diseases and with strictly observation of the therapeutic dose. Exceptional attention should be given when using the preparation on elderly patients and patients with debility; in cases with severe renal or liver failure; prostatic gland hypertrophy or ureteral sticture. As the medicine may provoke coordination disturbance, it should be used very carefully on driving and machinery operating persons.

Drug interactions

In concomitant administration with alcohol, barbiturates, benzodiazepine, hypnotic and sedative drugs, MAO-inhibitors and tricycled antidepressants Codterpin leads to intensification of its central depressive action on the central nervous system. Concomitant treatment with guanetidin, methyl-dopa and reserpine reduces its antihypertensive effect.

Adverse reactions

Following adverse reactions may be seen: respiratopry tract - depression of the respiration; cardiovascular system - hypotension, tachycardia, premature beats; hematologic - hemolytic anemia, thrombopenia, agranulocytosis; central nervous system - headache, sedation, coordination disorders, fatigue, insomnia, diplopia, neuritis, convulsions; gastrointestinal system - xerostomia, appetite loss, nausea, vomiting, diarrhea, constipation; urinary system - disuria, urine retention. Occasionally rash and photosensitivity are seen. Long-term administration of the preparation leads to drug dependence (codeine-dependence) manifesting with abstinence after medicine interruption.

Pharmacological mechanisms

Codterpin is a combined preparation possessing antitussive and expectorant action. Codeine, as a preparation constituent, depresses the cough reflex, inhibiting directly the cough center in the brainstem. In therapeutic dose it does not depress the respiratory center. The preparation possesses weak sedative and analgesic effects. Terpin hydrate facilitates the elimination of the resilient bronchial secretion, as it is excreted by the lungs and liquefies the secretion. Exerts weak antiseptic effect on the pulmonary parenchyma. Sodium hydrogen carbonate liquefies the respiratory tract secretion and facilitates its elimination.

Supplied

10 or 400 tablets.

Expiry

3 years.

Manufacturer Sopharma AD: www.sopharma.com
 
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