International generic name
Drug form and composition
Solution for injection. One ampoule of 2 ml (2.5%) contains 50 mg Chlorpromazine
hydrochloride (25 mg per ml). One ampoule of 5 ml (0.5% or 1%) contains 25 mg (5
mg per ml) or 50 mg (10 mg per ml) Chlorpromazine hydrochloride.
Neurosis, manifesting with emotion; tetanus - as a part of the combined therapy.
In mental disorders - schizophrenia; chronic paranoid conditions; maniacal phase
of cyclophrenia; alcohol psychosis; chorea minor. In nausea and vomiting of different
causes; in serious singultus; in the treatment of acute porphyria. In surgery and
anesthesiology: for preparation of the patient for narcosis; in postoperative and
Dosage and administration
The preparation is administered parenterally - intramuscularly and intravenously.
In order to reduce the irritation effect of the medicine, intramuscularly are injected
low concentration solutions (0.5%). In intravenous application, because of the acid
reaction of the solution, it should be previously diluted in 10-20 ml glucose or
saline and injected slowly. Adults: in mental disorders - 25-50 mg single dose,
as the same dose may be repeated after 1 hour; in cases of vomiting and serious
singultus - intramuscularly in single dose 25 mg, as the same dose may be injected
repeatedly each 3-4 hours; as an anxiolytic - intramuscularly in dose 12.5-25 mg.
Maximal dose should not exceed 1 g/24h. Only in rare cases the dose may reach 2
g, but for a short time.
Severe liver diseases; hypersensitivity to Chlorazin; epilepsy; severe renal
failure; Parkinson’s disease; coma and acute injuries of the brain; cardiovascular
diseases; respiratory tract disorders; hypotension; stomach and duodenal ulcer;
hyperprolactinemia; pregnancy and nursing.
Special warnings and precautions
In patients with chronic pulmonary diseases (pulmonary emphysema, asthma) Chlorazin
should be administered with care. The preparation should be administered with care
in children, as they are predisposed to development of neuromuscular and extrapyramidal
reactions. Particularly high risk exists in children with dehydration and acute
infectious diseases (i. e. varicella and small pox). In elderly patients the preparation
should be used with particular care, as they usually require lower dose. The patients
with mental syndromes should be treated with 1/3 to 1/2 of the usual dose. The treatment
with Chlorazin may cause leucopenia and thrombopenia, which increases the risk of
microbial infections, retardation of the wound recovery, and gum bleeding. In patients
with history for convultions the preparation should be used with care, as it may
provoke such a symptom.
Chlorazin potentiates effects of the medicines, depressing the central nervous
system - anesthetics, barbiturates, narcotic analgetics, alcohol; reduces the effect
of the oral anticoagulant drugs, sulphonylurea antidiabetic preparations, levodopa,
guanethidine, insulin, and metformin. In concomitant administration with propranolol
the plasma level of both medicines is elevated. Chlorazin reduces the anticonvulsive
effect of the phenobarbital and other antiepileptic drugs, diminishing the convulsion
threshold. Diuretics and antihypertensive medicines may worsen the orthostatic hypotension,
caused by Chlorazin.
Parkinson's syndrome and dyskinesia; xerostomia; dystonia - more frequent in
children; gastrointestinal disorders; accommodation disorders; urine retention;
mechanic jaundice; photosensitization; menstruation disorders; galactorrhoea; gynecomastia;
Chlorazin is phenothiazine neuroleptic, possessing dopaminergic, adrenolytic,
cholinolytic, serotoninolytic and antihystamine (on the H1 receptors) effects in
the brain structures. It reduces enhanced emotional and motor excitation, but contrary
to barbiturates, even in high dose, does not lead to narcosis. The medicine depresses
the trigger zone, which is the cause for relive of the nausea, vomiting and intoxication
in infectious diseases. In long-term treatment Chlorazin exerts antipsychotic action
- wild ideas and hallucinations are relived and the normal mental activity are restored.
It is supposed that many of the central effects are related to blocking of the D2-dopamine
receptors in different parts of the brain.
100 ampoules of 2 ml (50 mg). 50 ampoules of 5 ml (25 mg). 50 ampoules of 5 ml