INSULIN MONO NS
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| StockNo |
Product description |
| EB0280-445-03 |
INSULIN
MONO NS VIAL 10 ML/400 IU |
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- COMPOSITION:
Crystal Insulin from porcine pancreas in neutral solution. 40
IU/ml. The preparation is produced from highly purified insulin
substance, obtained according to highly effective
chromatographic methods.
ACTION:
Insulin is a polypeptide hormone, which participates in the
regulation of carbohydrate, fat and protein metabolism. It increases
the transport of glucose through the plasma membranes of cells,
muscles, heart, fatty tissue and WBC, stimulates its oxidation and
increases the synthesis and the cumulation of glycogen in the liver
and muscles. Insulin stimulates the inclusion of the fatty acids
into Kreb's cycle, increases the triglyceride depots in fatty tissue
and decreases the formation of keto-bodies. The changes in
carbohydrate metabolism are characterized by prevalence of the
anabolic processes. Insulin realizes its numerous effects by binding
to the specific insulin receptors, which have membrane localization.
PHARMACOKINETICS:
Insulin Mono NS exercises a rapid and very strong hypoglycemic
effect. The action is manifested within the first half-hour after
subcutaneous injection, reaches its maximum after 1-2 h and usually
lasts 6-8 h. insulin Mono NS possesses weaker antigenic properties
because its structure is close to that of human insulin.
INDICATIONS:
Insulin-dependent diabetes mellitus with different gravity of the
disease; diabetic coma or precoma; acidosis as a result of severe
metabolic disturbances; strong load of the carbohydrate metabolism
as a result of bad infections, traumas and operations.
CONTRAINDICATIONS:
Absolute contraindications are not known until now. A relative
contraindication is the insulin allergy of "immediate
type."
SIDE EFFECTS:
Lipodystrophy or transitory edema in the site of application, if the
place of injection is not changed. Allergic reaction of
"immediate type" (erythema, eruption and itching) may be
observed very rarely. |
DRUG INTERACTIONS:
The hypoglycemic action of Insulin decreases when it is applied
simultaneously with glucagon, adrenomimetics, betablockers,
phenothiazine derivatives, salicylates, butadion, glycocorticoids,
preparations from the posterior part of hypophysis, gas narcotics,
thiazide diuretics and urosemid, while iprasid, clofibrate, ethyl
alcohol and oral antidiabetic drugs increase it. Insulin enhances
the antituberculosis action of PAS. Insulin and strophantin have a
contrary action, that is why a mutual reduction and even inversion
of their effects are possible.
PRECAUTIONS:
Hypoglycemia may occur as a result of heavy physical loads, in cases
of irregular meals, vomiting, nephropaty in advanced stage, chronic
hepatic diseases, Addison's disease, decreased function of the
thyroid and pituitary glands, as well as after a higher dose or
hypersensitivity to insulin. Every patient must be informed about
the main symptoms of hypoglycemia - headache, strong excitability,
restlessness, stupor, bulimia, tremor, increased perspiration, sleep
disturbances, speech and vision disturbances, psychic disturbances
with depressive character up to loss of consciousness.
In case of hypoglycemia, the patient must take immediately sweetened
tea or sugar. The hypoglycemic coma is treated with 40 % glucose
solution i.v., in severe conditions 1 ml of 0.1 % solution of
adrenalin or glucagon may be also applied.
DOSAGE AND ADMINISTRATION:
Insulin Mono NS is applied subcutaneously, intramuscularly,
intravenously, and by means of dropwise infusion in comatose
conditions. The subcutaneous injections and in rare cases the
intramuscular injections are made 15 min before meals. The dose is
strictly individual, determined by a doctor on the basis of the data
of blood sugar profile and the calculations of the carbohydrate
balance. For adults the daily dose ranges between 8 and 24 h.
Before use, the vial must be shaken and the suspension should be
injected immediately after aspiration. Different kinds of insulin
preparations should not be mixed in one syringe because of the
different pH of the solution.
MEDICINAL FORM AND PACKAGE:
Vials of 400 IU/10 ml in packs of 1 or 5.
STORAGE:
At temperature from 2 to 8° C.
DO NOT FREEZE!
EXPIRY:
2 (two) years.
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