AMPOULE 20 MG/ 1 ML (2%)
VIAL 10 ML 2 % SOLUTION
SUPPOSITORIES CHILDREN 7.5 MG X 6
SUPPOSITORIES ADULTS 10 MG X 6
FILMTABL X 20
Hyoscine butylbromide 20 mg/1 ml in one ampoule; 20 mg in 1 ml
solution; 5 mg in 5 ml syrup; 7.5 mg in one suppository for
children, 10 mg in one suppository for adults; 10 mg in one
Buscolysin is a quaternary ammonium derivative with peripheral
anticholinergic action. It inhibits the transmission of nervous
impulses in the ganglia and at the same time it has a
parasympatholytic action. Buscolysin decreases the smooth muscle
tone of the gastrointestinal and urogenital tract, inhibits the
secretion of the bronchial, salivary and sudoriferous glands, and in
higher doses - the secretion of gastric glands. In the same doses it
also blocks the accommodation of the eye.
Administered orally, it is partially absorbed due to its low lipoid
solubility - about 5 %, and after rectal application - about 2 %
from the dose. The bioavailability of the preparation is low in all
forms of administration. With parenteral administratiopn, the
half-life time is about 5 h, 50 % of the administered dose being
excreted with urine. A small part of the drug is eliminated
unchanged with the bile.
Spastic states of the stomach and duodenum, biliary ducts and
urogenital system. Facilitation of endoscopic examinations and
functional diagnosis during examination of the gastrointestinal
tract. During labor, for accelerating the dilation of cervix uteri.
Mechanical stenisis of the gastrointestinal tract. Urine retention
due to prostate adenoma, glaucoma, tachycardia and myastenia gravis.
Anticholinergic effects can be observed with higher doses:
inhibition of saliva and sudor secretion, disturbances in miction
and acceleration of cardiac rhythm. Reactions of hypersensitivity
are likely to occur in individual cases: most often - urticaria, and
rarely - shock.