AMPOULE 20 MG/2 ML
TABL 40 MG X 50
Furosemide 20 mg in one ampoule and 40 mg in one tablet.
Furanthril is a potent diuretic with a fast and short action,
realized by the lumen side of the epithelium of the renal tubules in
the ascending limb of Henle's loop. It increases the selective
excretion of sodium ions to a maximum of 35 %, and stimulates the
renin-angiotensin-aldosterone system, depending on the dose. Prior
to the renal diuretic effect, furanthril reduces the overload of the
heart by dilating the capacitive vessels, in preserved renal
function and absence of marked edemas.
The diuretic effect of the drug is about 6 h after oral
administration, intravenously - from 2 to 3 h. Half-elimination time
in serum after oral administration of 40 mg furanthril is about 3.5
h in healthy subjects and in patients with impaired renal function
it is 13.5 h on the average.
More than 90 % of furanthril were found to be excreted through the
Edemas resulting from cardiac, hepatic and renal diseases, and as a
result of burns. Acute and chronic cardiovascular insufficiency, in
combination with other drugs. Hypertension (particularly in affected
renal function and hypertonic crises).
In the complex therapy of pulmonary and cerebral edema.
In toxicoses of pregnancy progressing with oliguria.
For maintaining forced diuresis in intoxications.
For prophylaxis of acute renal insufficiency (threatening or
advanced shock). For treatment of hypercalcemic crises.
Grave hepatic insufficiency (hepatic coma), renal insufficiency
accompanied by anuria or oliguria; hypokalemia; hypersensitivity to
furanthril and sulfonamides; reduced blood volume (hypovolemia),
with or without concomitant reduction of blood pressure
Hypokalemia, hyponatremia, hypocalcemia, hypovolemia are likely to
occur after long-term administration of high doses of furanthril, as
well as dehydration and a tendency to thrombosis and other disorders
of the water-electrolyte balance of the organism.
Sometimes allergic reactions can be observed in predisposed
patients: skin rashes and changes in the blood count (leukopenia,
agranulocytosis, thrombocytopenia). Anaphylactic shock is a rare
A transitory elevation of creatinine, urea, chelesterol and
triglycerides in blood may result from furanthril treatment.
An existing diabetes can be deteriorated in rare cases or a latent
diabetss can be manifested.
Transotory disorder in hearing and orthostatic collapse are possible
after last intravenous administration of furanthril.
Furanthril should be administered to pregnant women only after
accurate evaluation of the indications. To breast-feeding mothers
the fact that the drug passes into the milk and that it suppresses
lactation should be borne in mind. It is recommended to stop
breats-feeding in such cases.
Furanthril administration to drivers and to subjects operating
machines can disturb their fitness for active performance.