Welcome to Sopharma AD A Prominent Name in Public Healthcare!
Back to Sopharma Home page Contact us  
Welcome to www.sopharma.com
16 Iliensko Chausee St.
Sofia, Bulgaria 1220
 


Non-Steroid Anti-Inflammatory Drugs

. Analgin
. Anapyrin
. Amidophen
. Feloran
. Indomethacin
. Paracetamol
. Piroxicam
. Sedalgin


Phytochemical Products from Plant origin

. Tribestan
Phytin
Carsil
Nivalin
Tabex
Palmcarotenol
Clinogel


Pharmaceutical substances

. Silymarin
. Cytisine
. Esculin
. Galantamine bromide
. Glaucin hydrobromide
. Phytin
. Peflavit
. Tribulus terrestris
. Valerian dry extract


Pharmaceutical products

Fifteen categories
 

 

 

 

 

 

 

PIROXICAM

 
 
StockNo Product description
EB0280-421-11 PIROXICAM CAPSULE 10 MG X 20
EB0280-421-27 PIROXICAM CAPSULE 20 MG X 20
EB0280-421-28 PIROXICAM SUPPOSITORIES 20 MG X 5
 
COMPOSITION:
Piroxicam
10 and 20 mg in one capsule and
20 mg in one suppository

ACTION:
Piroxicam is a non-steroid antiphlogistic agent from the group of oxicams. It has a strong antiphlogistic, analgesic and antipyretic effect. Its mechanism of action is primarily due to the inhibition of prostaglandins synthesis. Similar to other non-steroid antiphlogistic agents, piroxicam inhibits the second phase of platelet aggregation.

PHARMACOKINETICS:
It has a very good gastrointestinal absorption. It binds with plasma proteins in about 98 %. Its plasma half-life is about 40 h, making it suitable for administration in single doses. About 95 % of the drug is metabolized and excreted mainly with the urine, and only an insignificant part with the feces.

INDICATIONS:
Inflammatory articular diseases - rheumatoid arthritis, ankylosing spondylarthritis, etc.; highly activated and painful degenerative articular diseases - arthrosis, spondylosis; acute stage of rheumatism of soft tissues - bursitis, synovitis, tendovaginitis; acute painful posttraumatic and postoperative states; acute gout attack.

CONTRAINDICATIONS:
Gastric and duodnal ulcer, susceptibility to bleeding, hypersensitivity to aspirin or other non-steroid antiphlogistic agents (particularly if they have induced asthmatic paroxysms, allergic rhinitis or urticaria), pregnancy and breast-feeding. It is not administered to children below the age of 8 years.

SIDE EFFECTS:
Gastrointestinal disturbances - nausea, sense of heaviness, diarrhea, dyspersia, peptic ulcers, hemorrhages from the gastrointestinal tract. Those disturbances are usually dose-dependent.
As regard the CNS - sleep disorders, headache, dizziness may be observed.
The most frequent skin reaction are rashes, itching, photosensitivity. Cardiovascular and renal disturbances, suppression of bone marrow function (granulocytopenia, anemia) may occur very rarely.

DRUG INTERACTIONS:
Systematic medical control is necessary in simultaneous administration with pharmaceuticals that bind with plasma proteins to a high percentage. Aspirin and other non-steroid antiphlogistic agents reduce the effect of piroxicam (due to competition for serum proteins). Piroxicam diminish the effect of diuretics and other hypotensive agents, while enhancing the effect of lithium drugs.

PRECAUTIONS:
Piroxicam can weaken attention and reactions, which should be taken into consideration when the drug is prescribed to drivers and machine operators. That action of piroxicam is enhanced by simultaneous intake with alcohol. It should be administered cautiously to petients on maintenance anticoagulant therapy, with regular control of paraclinical indices.

DOSGAE AND ADMINISTRATION:
Capsules: a single dose of 20 mg is administered daily to adults. In more severe and painful conditions - a single dose of 40 mg. After the abatement of the acute complaints - 20 mg daily.
Suppositories: one suppository daily is applied to adults, and the dose can be repeated in very acute inflammatory processes with concomitant pain syndrome. To children from 8 to 16 years - 1 suppository daily. Maximum course of treatment - from 5 to 8 days.

MEDICINAL FORM AND PACKAGE:
Packages with 20 capsules of 10 and 20 mg.
Packages with 5 suppositories of 20 mg.

STORAGE:
In a place protected from light, at a temperature from 15 to 30 C for capsules and 5-15 C for suppositories.

EXPIRY:
3 (three) years.

 

 

Central nervous system Bellergamin Centrophenoxine Chlorazin Cinnarizine Diazepam Haloperidol Lydol Morphine Natrium bromatum Phenobarbital Piracetam Tempalgin Tilidine adrenaline Atropine Lidocaine Nivabex Nivalin Pymadin Tabex Cardiovascular Antistenocardin Atenolol Captopril Chlophadon Chlophazolin Diltiazem Furosemide Isocor Naniprus Pentofyllin Pharmacynon Vasopren Digestive system Ranitidine Sopral Pulmonary system Bromhexin Broncholytin Codterpin Dimex Glauvent Salbutamol Sophafyllin Amidophen Analgin Feloran Indomethacin Paracetamol Piroxicam Buscolysin Papaverine Antibiotic Amikacin Chlorquinaldol Ethambutol Gentamicin Rimicid Progesterone Testosterone Allergosan Ketotifen Vitamins, Minerals & Enzymes Calcium Phospho C Deavit Deflamol Peflavit C Vitamins Furotalgin Pilocarpine Rhinolex Sulfacetamide Mycodermin Revulsan Univertan Zinc ointment Phytin Tribestan Antistrumin Bisacodyl Calcium gluconicum Glibenclamide Methilprednisolone Natrium citricum Natrim chloratum Phlebescin

1999-2001 Sopharma USA Corporation. All rights reserved.
Copyright, Trademark, Disclaimer and Privacy statement.

A service of Bulgarian Pharmaceutical Group Ltd.

EB0280 01/28/2001