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Vegetotropic Drugs

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Phytochemical Products from Plant origin

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Phytin
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Nivalin
Tabex
Palmcarotenol
Clinogel


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. Silymarin
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. Peflavit
. Tribulus terrestris
. Valerian dry extract


Pharmaceutical products

Fifteen categories
 

 

ATROPINE SULFATE

 
 
StockNo Product description
EB0280-418-02 ATROPINE SULFATE AMPOULE 1ML/0.1%
EB0280-418-23 ATROPINE SULFATE VIALS 10 ML 1%
 
COMPOSITION:
Atropine sulfate 0.1 % /l ml in one ampoule and 1 %/10 ml isotonic solution (collyr).

ACTION:
Atropine is an alkaloid from Atropa belladonna L. it blocks the M-cholinoreceptors and disturbs the transmission of nerve impulses from the postganglionic cholinergic nerves to the effector organs: salivary, bronchial and sudoriferous glands, heart, smooth muscles of the digestive system and eyes. It has a slight effect on the N-cholinergic receptors in therapeutic doses.
Atropine inhibits the secretion of the sudoriferous, salivary, gastric and bronchial glands, and of pancreas. It reduces the tone of the bronchial muscles, relaxes the smooth muscles of the gastrointestinal tract, biliary and urinary ducts. It dilates pupils and induces paralysis of accomodation. Its central M-cholinolytic action is associated with reduction of tremor and decrease of muscle tone in parkinsonism, excites respiration and in high doses paralyses the respiratory center. It accelerates cardiac rhythm and improves the His bundle conductivity.

PHARMACOKINETICS:
It is well absorbed after oral administration, its plasma half-life is from 18 to 38 h, and its binding to plasma proteins is about 50%.

INDICATIONS:
Administered in the complex therapy of ulcer disease, pylorospasm, cholecystitis, cholelithiasis, gastric, biliary and renal colic, bronchial asthma, etc. for treatment of acute intoxications with cholinomimetics, postencephalic parkinsonism, digitalis intoxications, etc. it is used with diagnostic and therapeutic purpose for inducing mydriasis and paralysis of eye accomodation.

CONTRAINDICATIONS:
Its application is contraindicated in glaukoma, hypertrophy of prostate and postoperative paresis of the urinary bladder and intestines, active form of pulmonary tuberculosis and cardiac decompensation.

SIDE EFFECTS:
It induces specific, so-called atropine-like side effects: dryness in the mouth, mydriasis, increased ophthalmotone, palpitation, obstipation and urine retention. In high doses it can induce motor and psychic excitation, hallucinations, convulsions and arterial hypotension.

DRUG INTERACTIONS:
Atropine reduces the analgesic action of opiates. The toxic action of MAO-inhibitors is potentiated in combined therapy (tachycardia and arrhythmia); with digitalis drugs it contributes to the disorder of the cardiac rhythm. Potentiates the cholinolytic effect of chinidine and novocainamide. It antagonizes the M-cholinomimetic effect of nivalin, pilocarpine, neostigmine, etc.

DOSAGE AND ADMINISTRATION:
Collyr - topically applied. For cycloplegia - 1-2 drops, two times daily until the desired effect is attained (3-5 days on the average); therapeutically - it is applied in the lower conjunctival sac - 1-2 drops, 2-5 times daily.
Ampoules: parenterally injected - subcutaneously, intramuscularly or intravenously in doses from 0.25 to 1 mg, 1-3 times daily. The maximum daily dose for adults is 3 mg. Atropine can be applied every 15 min in doses of 1 mg intramuscularly or intravenously in intoxication with phosphororganic compounds.

MEDICINAL FORM AND PACKAGE:
Packages with 10 and 50 ampoules of 1 ml/0.1 %.
Vials of 10 ml with eye drops of 1 %.

STORAGE:
At moderate temperature (15-30 C).

EXPIRY:
5 (five) years.

 

 

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EB0280 01/28/2001