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CODEINUM PHOSPHORICUM
| StockNo |
Product description |
| EB0280-410-08 |
CODEINE
PHOSPHATE TABL 10 MG X 10 |
| EB0280-410-27 |
CODEINE
PHOSPHATE TABL 20 MG X 10 |
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- COMPOSITION:
Codeine phosphate 10 mg and 20 mg in one tablet
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- ACTION:
Codeine phosphate is a piperidinophenantrene alkaloid of opium,
with good antitussive and weaker analgesic effect. The
antitussive effect is due to its direct selective inhibitory
action on the cough center in medulla oblongata. Its
administration in therapeutic doses hides no danger of
suppressing the respiratory center. It has a week sedative
effect and its prolonged administration leads to constipation.
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- PHARMACOKINETICS:
The preparation is absorbed very well when administered orally,
it is distributed uniformly and passes rapidly the
hematoencephalic barrier. The elimination takes place by
glucuronide binding which leads to increased intoxication in
early childhood. About 80% of the preparation is excreted with
the urine in the form of metabolites, the rest is unchanged. Its
biological half-life is from 3.9 to 5.3 hours for healthy
people.
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- INDICATIONS:
The preparation is used mainly for suppressing the cough in
bronchitis, whooping cough, etc. (predominantly in case of dry
cough without secreta in the bronchial tree). As a weak
analgesic drug, also in cases of pain in the gastrointestinal
tract, in combination with other analgesic drugs.
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SIDE EFFECTS:
The prolonged administration of codeine phosphate leads to
constipation. Higher doses (0.1-0.2) may provoke a certain
excitement, nausea, heaviness in the head, insomnia and in
conditions characterized with bronchospasm (asthma or lung
emphysema) it may accelerate the development of heavy respiratory
insufficiency due to the increased viscosity of the bronchial
secreta and the suppression of the cough center. Prolonged use may
lead to drug-dependence.
DRUG INTERACTIONS:
The preparation enhances the central depressive action of alcohol,
barbiturates, benzodiazepines, hypnotics and sedative drugs.
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- PRECAUTIONS:
Prolonged use leads to addiction (codeinism), with symptoms of
adstinence when the treatment is discontinued. The preparation
should not be administered without any control.
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- DOSAGE AND ADMINISTRATION:
Adults - orally 10-20 mg, 3-4 times daily. Maximum daily dose -
300 mg.
Children (over 6 months) - 1-4 mg according to the age and the
general state.
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- MEDICINAL FORM AND PACKAGE:
Tablets of 10 mg and 20 mg in packs of 10.
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- STORAGE:
At moderate temperature (15-30 C).
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- EXPIRY:
5 (five) years.
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