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ALCOZIN
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Product description |
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| EB0280-410-02 |
ALCOZIN
FILMTABL X 20 |
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| EB0280-410-28 |
ALCOZIN
AMPOULE 2 ML |
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- COMPOSITION:
Atropine sulfate 0.5 mg
Codeine phosphate 20 mg
Promethazine hydrochloride 15 mg
Noramidopyrine methansulfonate sodium
- in one ampoule of 2 ml 500 mg
Atropine sulfate 0.5 mg
Codeine phosphate 20 mg
Promethazine hydrochloride 15 mg
Noramidopyrine methansulfonate sodium
- in one filmtablet 500 mg
ACTION:
The combination of the spasmolytic action of atropine with the
pain-relieving properties of codeine and analgin, complemented by
the central sedative and hypnotic effetc of promethazine, brings the
drug near to morphine in the intensity of pain-relieving action.
The risk of addiction to the drug, however, is far lower than to
morphine and to the synthetic analgesics of the morphine group.
Analgin is quickly absorbed and, in fact, completely with peroral
administration and 50% of the maximum concentration is attained
after 30 min. half-elimination time is about 7 h, 90% of the
elimination is realized through renal excretion.
Codeine is metabolized in the liver by glucuronization and thus it
has an enhanced toxicity in childhood. It is mainly excreted with
the bile, with a mean coefficient of elimination of 0.3-0.7.
Atropine absorption depends on the pH-values of the medium, and when
the pH-values of the gastric juice are low, absorption is slower in
the stomach and quicker in the intestines. Its binding to plasma
proteins ranges within 30-50%, promethazine binding being only 7.5%.
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INDICATIONS:
Acute pain syndrome with concominant spasms of the smooth muscles:
ulcer disease, biliary or renal colic. Neuralgia, post-operative
pain, in oncological practice.
CONTRAINDICATIONS:
Low blood pressure.
- SIDE EFFECTS:
Fast blood pressure drop is likely to occur after intravenous
injection.
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- PRECAUTIONS:
To be injected when the patient is in lying position. Due to its
hypnotic effect, the drug must be administered under hospital
conditions or at home. Prescribing the drug to outpatients
should be avoided! After its administration (irrespective of the
form), the patient should be forbidden to practice activities
requiring fast reflexes and sharp attention for several hours
(driving and machine operation).
DOSAGE AND ADMINISTRATION:
One ampoule, 3-4 times daily during strong pain - subcutaneously or
intramusculary. The intravenous injection should be slow when the
patient is in a lying position.
Orally - 1-2 filmtablets, one or two times daily.
MEDICINAL FORM AND PACKAGE:
Ampoules of 2 ml in packages of 10, 50 and 100.
Filmtablets in packages of 20.
STORAGE:
At moderate temperature (15-30 C), in a place protected from
humidity.
EXPIRY:
2 (two) years.
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