RIMICID
| StockNo |
Product description |
| EB0280-408-12 |
RIMICID
TABL X 100 |
-
- COMPOSITION:
Isonicotinoyl-hydrazide 100 mg in one tablet
ACTION:
Effective antitubercular drug with a very low toxicity and a narrow
spectrum of bactericide action. It suppresses the multiplication and
growth of mycobacteria but has no effect on the other
microorganisms. Rimicid dilates the peripheral and coronary vessels,
reduces the blood pressure, improves the function of the
gastrointestinal tract and excites the appetite.
PHARMACOKINETICS:
It is very well absorbed in the digestive tract - up to 90 % in the
absence of inflammatory processes in the stomach and intestines. The
maximum concentration of the drug in blood plasma is attained within
about 1-2 h after its intake and its plasma concentration is reduced
to 50 % within 6 h. It is excreted via the kidneys predominantly,
unchanged in 10 to 15 % and the rest of the drug undergoes
biological transformation and is eliminated with the urine as
metabolites.
INDICATIONS:
It is administered as a basic tuberculostatic in all forms of
tuberculosis. It can be used for chemoprophylaxis of tuberculosis in
patients susceptible to that disease (diabetics and patients on
systematic corticosteroid therapy), or in patients with past history
of tuberculosis. Rimicid can be combined with all other
tuberculostatics. |
CONTRAINDICATIONS:
Epilepsy, convulsions in mentally disturbed patients, lesions of the
optic nerve and polineuritis.
SIDE EFFECTS:
Headache, tinnitus, lower systolic blood pressure, paresthesia,
insomnia, memory disturbances, neuritis, ataxia. Very rarely
allergic reactions, agranulocytosis, eosinophilia and
chemoglobinemia can be observed.
DRUG INTERACTIONS:
Combination of Rimicid with PASA, rifampicin, streptomycin or
etambutol is recommended with a view to avoiding the emergence of
resistant strains.
DOSAGE AND ADMINISTRATION:
It is administered orally - 5 to 10 mg/kg body weight, divided into
three intakes. When necessary, the dose can be increased from 600 to
900 mg for 24 h. the dose is reduced by 20 to 25 % in elderly
patients or patients with body weight below 50 kg.
MEDICINAL FORM AND PACKAGE:
Packages with tablets of 100 mg.
STORAGE:
At moderate temperature (15-30° C), in a place protected from
moisture.
EXPIRY:
5 (five) years.
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