VITAMIN B1

StockNo	Product description
EB0280-101-16	VITAMIN B1 AMPOULE 5 MG/1 ML (0.5%)
EB0280-101-28	VITAMIN B1 AMPOULE 8 MG/2 ML (4%)

 

COMPOSITION:
Thiamine chloride 5 mg/1 ml; 80 mg/2 ml in one ampoule.

ACTION:
Vitamin B1 plays an important role in carbohydrate metabolism. It is a component in the co-enzyme of transketolases, which facilitate the disintegration of the carbohydrates through the pentosophosphate cycle, and it accelerates the oxidative decarboxylation of pyruvic acid and 2-oxy-glutaric acid. Thiamine potentiates the action of the mediator acetylcholine and improves the function of neurons. The daily need of the organism of Vitamin B1 depends on the quantity of carbohydrates introduced and is calculated on the basis of 0.4 mg per 1000 kcal.

PHARMACOKINETICS:
Parenterally administered, Vitamin B1 is metabolized in the liver. Part of it is to be subjected to enterohepatal turnover by the bile and to reverse reabsorption through the duodenal wall. Usually, its blood concentrations reach from 2 to 4 mkg/100 ml. The drug is eliminated as metabolites with the urine, its half-elimination time being about 10-20 days.

INDICATIONS:
Vitamin B1 deficiency due to the intake of vitamin-poor food, disordered absorption of Thiamine in the gastrointestinal tract (alcoholism) or increased need (pregnancy, lactation).
Inflammatory and degenerative processes of peripheral nerves (alcoholic, postinfectious polyneuritis, sciatica, radiculitis), alcoholic cardiomyopathy, Wernicke's encephalopathy.
Avitaminosis B1 (beriberi), dry and wet form, is manifested by muscular weakness, paresthesia, paresis and paralysis.

SIDE EFFECTS:
The drug is well tolerated. Anaphylactoid reactions can occur in exceptionally rare cases after long-term administration of high doses. No conditions associated with hypervitaminoses B1 have been described.

DRUG INTERACTIONS:
Parallel administration of Vitamin B1 with Vitamin B12 and B6 in one syringe or infusion solution is not recommended because of the direct degradation of the vitamins by cobalt from Vitamin B12.

DOSAGE AND ADMINISTRATION:
Parenterally (intramuscularly or intravenously) Vitamin B1 is administered in a dose between 10 and 100 mg daily, 30 mg/day on the average. In conditions of severe avitaminosis, the dose can be increased to 600 mg daily.

MEDICINAL FORM AND PACKAGE:
Packages with 10, 50 and 100 ampoules of 5 mg/1 ml (0.5 %) and 80 mg/2 ml (4 %).

STORAGE:
At moderate temperature (15-30° C), in a place protected from light.

EXPIRY:
2 (two) years.