International generic name

Combined product

Drug form and composition

Film-coated tablets. One film-coated tablet contains: 150 mg Calcium hydrogenphosphate dihydrate; 70 mg Calcium lactate; 50 mg Calcium glycerophosphate; 20 mg Ascorbic acid.

Indications

Diseases accompanied by a calcium-phosphate balance disorders - hypocalcemia of different causes, osteomalacia, allergy predisposition, convalescence following severe disease; fractures, etc. In elderly patients with osteoporosis, for normalization of the calcium-phosphate exchange. Conditions with enhanced calcium demands - pregnancy, lactation, accelerated body growth, etc. In patients with diabetes, thyrotoxicosis, and following corticosteroid therapy for prevention the changes in bone structure.

Dosage and administration

In adult patients - 1-2 tablets, 3-4 times daily. In children over 6 years - 1 tablet 2-4 times daily. The dosage and duration of the treatment is determined by the doctor, depending on the severity of the disease. If necessary the preparation may be used in long-term treatment courses or short courses at intervals of several mounts.

Contraindications

The preparation should not be administered in patients with accelerated blood clotting; thrombophlebitis; predisposition to thrombosis; hypercalcemia; arteriosclerosis; chronic renal failure; severe liver disorders; prosthetic cardiac valves; glucoso-6-phosphate dehydrogenase deficiency; nephrolithiasis and hyperoxaluria; thalassemia.

Special warnings and precautions

Calcium phospho C should be used with care in persons with disturbed coagulation, as in such cases long-term administration requires monitoring of the coagulation status. During the treatment with the preparation is advisable to determine serum concentration of the phosphates, as well as to investigate the functional status of the kidneys. In patients with diabetes the medicine should be used carefully, as a risk of deterioration of the functional activity of the pancreatic beta-cells exists. In long-term application glucose level should be monitored.

Drug interactions

Calcium improves the action of the digitalis and elevates sensitivity to this medicine; reduces effectiveness of some local anesthetics. Concomitant administration of calcium preparations and tetracycline antibiotics reduces the absorption level of the later in the gastrointestinal tract, because of the formation of nonabsorbable complexes with calcium. Calcium preparations antagonized neural-muscular block, caused by amikacin and other amynoglycoside antibiotics. In concomitant use with barbiturates the excretion level of the later is reduced, their plasma level is elevated, and its pharmacology and toxic activity are intensified.

Adverse reactions

Most frequent adverse reactions are gastrointestinal manifestations - nausea, vomiting, gastrointestinal discomfort in patients with predisposition.

Pharmacological mechanisms

Calcium regulates membrane permeability, neuromuscular excitation, blood clotting, activating of several enzyme systems, and participates in the muscular contraction. Phosphorus plays a basic role in formation of the high energy compounds, including ATP and creatinphosphate; participates in formation of the bones and teeth. Calcium and phosphate metabolism in the organism is regulated by the parathyroid hormone and calcitonin. Calcium glycerophosphate, containing calcium and inorganic phosphate, stimulates mineralization of the teeth tissue and tubular dentine formation. Data exist that oral calcium possesses preventive effect concerning intestinal carcinogenesis. Ascorbic acid participates in the synthesis and exchange of the steroid hormones, and adrenaline; stimulates formation of the collagen structures in the bones, muscles and teeth; normalizes tissue exchange and respiration; activates prothrombin. It possesses anti-toxic and antioxidant activity. Reduces the enhanced permeability of the capillary vessels, and limits the exudative, inflammatory, and allergy reactions. As an antioxidant ascorbic acid may regulate directly free-radical reactive oxygen molecules. It stimulates the regeneration of the tissues and the growth.

Supplied

30 Film-coated tablets.

Expiry

2 years.