|
International generic name
Bromhexin hydrochloride
Drug form and composition
Bromhexin hydrochloride: 4 mg/2 ml in one ampoule; 2 mg in 1 ml solution and
4 mg in 5 ml syrup.
Indications
All forms of tracheobronchitis; emphysematous bronchitis, bronchiectasis with
inflammatory pulmonary diseases. Prior to and after surgical interventions with
general anesthesia, particularly in elderly patients.
The drug has pronounced mycolytic and secretolytic activity. It has a soothing
effect on cough and a slight emetic action. The mucolytic effect is associated with
depolymerization and splitting of mucoproteins and mucopolysaccharide fibres. It
has no effect on intestinal peristalsis. It is quickly absorbed in the gastrointestinal
tract and excreted with urine.
Dosage and administration
In adult patients is administered 10 ml syrup, 3-4 times daily. In children older
than 10 years the dosage is 10 ml, 3 times daily, and in children from 3 to 10 years
- 5 ml, 3 times daily.
Contraindications
Hypersensitivity to the drug.
Special warnings and precautions
Transitory gastrointestinal disturbances, perspiration. Irritation with cough
is likely to occur during inhalation. The adverse effects are transient. In single
cases, it can induce short-term elevation of serum transaminase.
Dosage and administration
Orally: adults - 4 ml of the solution, 3 times daily.
Children from 5 to 10 years - 2 ml 3-4 times daily; under 5 years - 20 drops, 3
times daily. Ten drops can be given to breast-fed infants, 2-3 times daily.
The treatment usually lasts 3-5 weeks (rarely months) for adults, being considerably
shorter for children.
Parenterally: 1 ampoule 2-3 times daily is prescribed in severe cases, to be injected
s. c., i. m. or i. v., but very slowly (for 2-3 min).
Inhalation: the solution is diluted with distilled water in a ration of 1: 1 and
inhaled: adults, 2 ml 2-3 times daily (with warmed solution); children, 5-10-20
drops, 1-2 times daily, depending on age. The inhalation can be combined with oral
intake of the preparation, which can enhance its action.
Supplied
Packages with 10, 50 and 100 ampoules of 4 ml/2 ml (0.2 %).
Solution 0.2 % in vials of 40 ml.
Syrup 0.08% in vials of 125 ml.
Expiry
3 years.
|