International generic name
Drug form and composition
Suppositories. One suppository (for children) contains 5 mg Bisacodyl (as 100%).
One suppository (for adult patients) contains 10 mg Bisacodyl (as 100%).
Chronic constipation in different diseases; for patient preparation before X-ray,
endoscopy and ultrasonography examinations, as well as in preoperative period; constipation
during pregnancy and before surgery.
Dosage and administration
For adult patients as a purgative - 10 mg (1 suppository) daily, rectally. For
children older than 6 years - 5 mg (one pediatric suppository), rectally.
Hypersensitivity to the medicine; ileus; acute inflammations of the abdominal
organs; gastrointestinal and vaginal bleeding; acute enterocolitis; dehydration;
rectal bleeding (fissure, laceration, hemorrhoids).
Special warnings and precautions
Bisacodyl should be used with care in elderly patients, in patients with cardiovascular
diseases (hypotension, chronic heart failure); in exhausted and febrile patients.
Bisacidyl should be used with care in cases with abdominal pain of unclear cause,
nausea and vomiting. In case of gastrointestinal discomfort with more than two weeks
persistence it is necessary to consult a physician before the treatment. Higher
doses of the preparation may provoke an abdominal pain, enhanced mucus secretion
and loss of significant quantities of water. It is advisable to start the treatment
with lower doses, which may be enhanced gradually if necessary. Long term administration
and graundless treatment should be avoided. Administration of Bisacidyl in children
younger than 6 years is not advisable. In pregnant women it should be used with
care, as the preparation enhances the rectal tone and leads to intensification of
the blood congestion in the pelvis.
Concomitant administration of Bisacidyl and several other drugs (particularly
oral anticoagulants) may lead to a shortening of their active absorbtion time, which
may require correction of the dose. Bisacidyl is a local laxative preparation, so
local anesthetics and narcotic agents reduce its activity. Cholinomimetic agents
(acetilcholine, pilocarpine, etc.), as well as adrenolytic agents (yohimbin, vasolat),
stimulate cholinergic innervation of the bowels and may potentiate the preparation
activity. In controversy, adrenomimetic and cholinolytic preparations may depress
its activity. Bisacidyl may raise the potassium loss if given together with thiazide
and loop diuretics, and glucocorticoids.
Nausea, abdomonal discomfort and meteorism; gripping abdominal pain; anal and
rectal inflammation; proctitis. In long-term treatment the preparation may cause
diarrhea, fluid and electrolyte loss. Tolerance to the preparation may develop also.
Bisacidyl is a diphenylmethane derivative. It intensifies the bowels peristalsis,
by stimulation of the sensor nerve ends in the bowels mucous membrane. Bisacidyl
stimulates water and electrolytes secretion in the bowel lumen; stimulates intestinal
passage and causes diarrhea due to activation of the nitric oxide synthesis. Its
mechanism of action makes Bisacidyl eligible for the treatment of constipation,
due to ganglion blocking or different spinal cord diseases (inflammation, intoxication,
mechanical damage). This preparation does not stimulate the uterus and does not
cause contractions. In rectal administration the effect is expected 15-30 minutes
6 suppositories of 5 mg and 10 mg.