International generic name
Drug form and composition
Solution for injection. One ampoule of 2 ml contains 20 mg Chloropyramine Hydrochloride
(10 mg/ml). Coated tablets. One coated tablet contains 25 mg Chloropyramine Hydrochloride.
Ointment. One gram of ointment contains 1% 10 mg Chloropyramine Hydrochloride. Cream.
One gram of cream contains 1% 10 mg Chloropyramine Hydrochloride.
As solution for injection Allergosan is used in acute states, associated with
Quincke’s edema, allergic reactions after insect bites, drug and food allergy. In
anaphylactic shock Allergosan is used as an element of the complex therapy. Tablets:
Allergosan tablets can be used for the treatment of allergic rhinitis, conjunctivitis,
hay fever, drug and food allergy, and allergic reactions after insect bites. Ointment
or cream: Allergosan ointment or cream is used for the treatment of skin allergic
Dosage and administration
Parenteral administration: In cases of severe allergic reactions 1 to 2 ampoules
can be injected intramuscularly or intravenously. Oral administration: In adults
1 tablet (25 mg) can be given 3 to 4 times daily (when necessary up to 150 mg);
in over 5 years-old children Allergosan can be given in dose of 1 tablet 2 or 3
times daily. External application: The affected zone should be treated one or several
times daily. During the application procedure ointment or cream should form a thin
Parenteral or oral administration: Adenoma of the prostate, acute peptic ulcer,
pyloric and duodenal stenosis, glaucoma, pregnancy, breast-feeding.
Special warnings and precautions
The medicine should not be used parenterally or orally together with alcohol,
sedative drugs and hypnotics because of the potentiation of the effects. Allergosan
should be used with caution in patients suffering from hyperthyroidism, cardiovascular
diseases, and bronchial asthma. In children Allergosan can induce agitation and
in many adult patients dizziness may be observed. Because of the pronounced sedative
effect the preparation should be prescribed cautiously in drivers and people working
Allergosan should not be used parenterally or orally concurrently with MAO inhibitors.
Because of the anticholinergic activity of Allergosan concurrent administration
with cholinomimetics is not advised. There is a possibility of increasing adverse
cholinomimetic effects. General anesthetics, analgesic agents and psycholeptics
potentiate the sedative effect of Allergosan.
After parenteral or oral administration Allergosan can induce: drowsiness, weakness,
vertigo, tiredness, dryness in the mouth, constipation, and more rare reactions
- visual disturbances and increase of intraocular pressure. In occasional cases,
contact allergy and photosensibilization are possible after external application
of the drug.
Allergosan is a representative of the classical antihistaminic agents - H1 antagonist.
As a competitive reversible antagonist of histamine against the H1-receptors, Allergosan
inhibits its effects. Allergosan inhibits the vasodilatation, increased vascular
permeability and tissue edema. In addition to the antiallergic and sedative effects
Allergosan also possesses a weak cholinolytic activity.
10 or 100 ampoules of 2 ml (20 mg). 20 coated tablets of 25 mg. Tubes containing
18 g ointment (1%). Tubes containing 18 g cream (1%).
Solution for injection and coated tablets - 5 years. Ointment and cream - 3 years.